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KMID : 0438420090160010023
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Korean Journal of Bone Metabolism
2009 Volume.16 No. 1 p.23 ~ p.28
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The Effect of Hop Based Dietary Supplement Containing Phytoestrogen in Ovariectomized Rat: A Bone Histomorphometric Analysis
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Yoo Ju-Seok
Kwon Soon Yong
Chung Jin-Wha
Park Jung-Keug
Kwon Soon-Ki
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Abstract
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To evaluate the effect of hop based dietary (ERDIC®, Glennrock B.V., Lunteren, Netherlands) intake against the estrogen deficiency induced osteoporosis in in vivo experiment, this study examined 4 groups of Sprague-Dawley rat classified by ovariectomy as well as dietary intake (Group I; Sham surgery, Group II; Sham surgery + ERDIC®, Group III; ovariectomy, Group IV; ovariectomy + ERDIC®). The rats in-group II and IV were fed a diet containing 3g of hop based dietary (3 tablet/day) for 3 months. Histomorphometric indices of cancellous bone of proximal tibia in 4 groups were measured respectively as follows; trabecular bone volume (bone volume/tissue volume, BV/TB), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), osteoid surface (OS/BS), eroded surface (ES/BS), mineralizing surface (MS/BS), mineral apposition rate (MAR), bone formation rate-bone volume reference (BFR/BV). The changes in BV/TV, TB.SP, OS/BS, ES/BS, BFR/BV were significant between group III and IV and group IV increased osteoid formation in microscope. We concluded that hop based dietary intake of genistein and diadzein, the primary isoflavone components, may be responsible for anti-osteoporotic effect in rat.
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KEYWORD
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Hop, Phytoestrogen, Osteoporosis, Ovariectomized rat
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